Abstract #1957

Case Study: Evaluation of White Matter Disorganization in Temporal Lobe Epilepsy

Laura Barlow¹, Irene Vavasour^1,2, David Li^1,2,3, Martin Parent⁴, and Doris Doudet³

¹UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ²Radiology, University of British Columbia, Vancouver, BC, Canada, ³Neurology, University of British Columbia, Vancouver, BC, Canada, ⁴Laval University, Quebec City, QC, Canada

Temporal lobe epilepsy (TLE) assessment on MRI is limited to qualitative analysis in the clinical environment. Diffusion Tensor Imaging has been used to interrogate white matter changes in TLE while Myelin Water Fraction has not. With this case study we compare diffusion tensor imaging with myelin water imaging in a non-human primate (NHP) with TLE and a healthy control to assess if the two methods are complementary in evaluating white matter disorganization.

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