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Abstract #1957

Case Study: Evaluation of White Matter Disorganization in Temporal Lobe Epilepsy

Laura Barlow1, Irene Vavasour1,2, David Li1,2,3, Martin Parent4, and Doris Doudet3

1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Columbia, Vancouver, BC, Canada, 3Neurology, University of British Columbia, Vancouver, BC, Canada, 4Laval University, Quebec City, QC, Canada

Temporal lobe epilepsy (TLE) assessment on MRI is limited to qualitative analysis in the clinical environment. Diffusion Tensor Imaging has been used to interrogate white matter changes in TLE while Myelin Water Fraction has not. With this case study we compare diffusion tensor imaging with myelin water imaging in a non-human primate (NHP) with TLE and a healthy control to assess if the two methods are complementary in evaluating white matter disorganization.

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