Abstract #1972

Periventricular innate immune cell activation drives tissue damage and clinical progression in multiple sclerosis

Emilie Poirion¹, Benedetta Bodini¹, Charline Benoit¹, Matteo Tonietto¹, Geraldine Bera¹, and Bruno Stankoff^1,2

¹Institut du Cerveau et de la Moelle épinière (ICM), Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Paris, France, ²Neurology Department, St Antoine Hospital, APHP, Paris, France, Paris, France

The objective of this study was to investigate the role of activated microglia in the periventricular damage of patients with MS, combining positron emission tomography with [18F]DPA714 and magnetisation transfert ratio (MTR). Using two-mm thick rings from the ventricular CSF surface to periventricular WM and thalamus, we describe the presence of a gradient of activated microglia together with a gradient of MTR, which correlate with the clinical worsening of patients. These results suggest that an increase of activated microglia and tissue damage might be triggered by the presence of CSF-derived factors, and could mediate the subsequent development of neuro-axonal irreversible damage in MS.

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