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Abstract #1973

Microglia activation in multiple sclerosis lesions drives structural changes over time and correlates with clinical progression

Matteo Tonietto1, Charline Benoit1, Emilie Poirion1, Geraldine Bera1, Mattia Veronese2, Federico E. Turkheimer2, Marco Battaglini3, Benedetta Bodini1, and Bruno Stankoff1

1Brain and Spine Institute - ICM, Paris, France, 2King's College London, London, United Kingdom, 3University of Siena, Siena, Italy

In this study we develop a new method to generate individual maps of activated microglia from 18F-DPA-714 positron emission tomography images and we use it to reproduce in-vivo the histopathological classification of multiple sclerosis white matter lesions. This method allowed us to identify chronically active lesions which are not detectable with standard MRI. These lesions were found to be the most structurally dynamic over time, having a higher chance of enlarging or shrinking after one year. Furthermore, a higher number of active lesions was associated with a more severe clinical progression.

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