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Abstract #1977

Comparison of Two Methods for the Measurement of T1 Hyperintensity in Multiple Sclerosis Patients with Repeated Exposure to Gadolinium-Based Contrast Agents

Megan Hii1, Heejun Kang1,2, Megan Le1, Andrew Riddehough1, Anthony Traboulsee1, Shannon Kolind1, David Li1,2, and Roger Tam1,2

1MS/MRI Research Group, Division of Neurology, University of British Columbia, Vancouver, BC, Canada, 2Dept of Radiology, University of British Columbia, Vancouver, BC, Canada

Exposure to gadolinium-based contrast agents is associated with long-term increase in T1 signal intensity in deep grey brain structures, but the measurement methodologies have not been well investigated. We propose marking regions of interest (ROIs) on registered serial T2w images, and compared two methods for measuring the signal changes in the corresponding T1w images: 1) Align the T1w to the T2w images (T2-space), and 2) Map the ROIs marked on the T2w images to the T1w images (T1-space). Applying these methods to frequent and infrequent scanning cohorts, we found signal increase to be associated with GBCA exposure, and T1-space is more sensitive.

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