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Abstract #1978

Gadolinium retention in the brain – an MRI relaxometry study comparing linear and macrocyclic types of gadolinium based contrast agents

Yngve Forslin1,2, Juha Martola1, Sara Shams1, Åsa Bergendal1, Maria Kristoffersen-Wiberg1, Sten Fredrikson1, and Tobias Granberg1

1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, 2Department of Radiology, Karolinska University Hospital, Stockholm, Sweden

Gadolinium contrast agents (GBCAs) have been shown to be retained in the brain after multiple linear GBCA administrations. We aimed to quantitatively investigate T1 in relation to linear and macrocyclic GBCA-administrations in DN and GP by relaxometry. 80 MS patients who had received different types of GBCAs, were consecutively recruited. This study, in line with previous studies using semi-quantitatively methods, showed that exposure of GBCA leads to shorter T1 relaxation using linear GBCA in comparison to patients who had received macrocyclic types of GBCA, as well as patients without GBCA exposure and healthy controls.

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