The definition of benign multiple sclerosis (BMS) is based on long disease duration and low level of disability, without considering cognitive deficits. Aim of the study was to apply voxel-wise methods to investigate whether cognitive dysfunction in BMS patients is associated with specific patterns of regional damage in the brain gray matter (GM) and white matter (WM). High-resolution T1-weighted and diffusion tensor MRI scans were acquired from 50 healthy controls and 38 BMS patients, 42% of which were classified as cognitively impaired. Distinct regional patterns of abnormalities, functionally relevant for cognitive processing, were associated with cognitive impairment in BMS patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords