Abstract #1991

Multiple Sclerosis Gray Matter Shows Greater Abnormalities in Phosphate Metabolites than White Matter

Manoj K Sammi¹, Yosef Berlow², Randy West^1,3, Katherine Powers¹, Vijayshree Yadav^3,4, Dennis Bourdette³, Rebecca Spain³, and William D Rooney^1,3

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²The Warren Alpert Medical School, Brown University, Providence, RI, United States, ³Department of Neurology, Oregon Health & Science University, Portland, OR, United States, ⁴MS Center of Excellence West, VA Portland Health Care System, Portland, OR, United States

Phosphate metabolite distribution in gray matter and white matter in human brain is compared between healthy control (HC) and subjects with Multiple Sclerosis (MS) using ³¹P Magnetic Resonance Spectroscopic Imaging (MRSI) at 7T. Phosphate metabolites are decreased in GM in MS compared to healthy controls.

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