Abstract #1994

Test-retest reproducibility of quantitative susceptibility mapping in a multi-site study on Alzheimer disease: effect of reference region of interest choice

Anna Nigri¹, Giovanni Giulietti², Cristina Muscio³, Giovanni B Frisoni^4,5, Maria Grazia Bruzzone¹, Marco Bozzali², Daniela Perani⁶, Pietro Tiraboschi³, Claudia Ambrosi⁷, Massimo Caulo^8,9, Pietro Chiarini¹⁰, Elena Chipi¹¹, Stefano Chiti¹², Enrico Fainardi¹³, Stefania Ferraro¹, Cristina Festari⁴, Roberto Gasparotti⁷, Ruben Gianeri¹, Andrea Ginestroni¹³, Andrea Ginestroni¹³, Lorella Mascaro¹⁴, Riccardo Navarra⁸, Lucilla Parnetti¹¹, Alberto Redolfi⁴, Laura Serra², Roberto Tarducci¹⁵, Fabrizio Tagliavini^3,16, and Jorge Jovicich¹⁷

¹Neuroradiology Department, Neurological Institute "Carlo Besta", IRCCS Foundation, Milan, Italy, ²Neuroimaging laboratory, IRCCS Santa Lucia Foundation, Rome, Italy, ³Division of Neurology V/Neuropathology, Neurological Institute "Carlo Besta", IRCCS Foundation, Milan, Italy, ⁴Laboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio-FBF, Brescia, Italy, ⁵Memory Clinic and LANVIE-Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland, ⁶Nuclear Medicine Unit, IRCCS San Raffaele Hospital, Milan, Italy, ⁷Department of Diagnostic Imaging, Neuroradiology Unit, University of Brescia, Brescia, Italy, ⁸Department of Neuroscience, Imaging and Clinical Sciences, University “G. d’Annunzio” of Chieti, Chieti, Italy, ⁹Institute for Advanced Biomedical Technologies (ITAB), University “G. d’Annunzio” of Chieti, Chieti, Italy, ¹⁰Neuroradiology Unit, Department of Diagnostic Imaging, R. Silvestrini Hospital, Perugia, Italy, ¹¹Centre for Memory Disturbances, Lab of Clinical Neurochemistry, University of Perugia, Perugia, Italy, ¹²Department Health Professions - U.O.c Research and Development, Careggi University Hospital Florence, Florence, Italy, ¹³Department of Neuroradiology, Careggi University Hospital Florence, Florence, Italy, ¹⁴Medical Physics Unit, Spedali Civili di Brescia, Brescia, Italy, ¹⁵Section of Neurology, Center for Memory Disturbances, University of Perugia, Perugia, Italy, ¹⁶Scientific Direction, Neurological Institute "Carlo Besta", IRCCS Foundation, Milan, Italy, ¹⁷Center for Mind/Brain Sciences, University of Trento, Mattarello, Italy

Quantitative susceptibility mapping (QSM) is a neuroimaging marker of iron of interest as biomarker of Alzheimer disease (AD) progression. The purpose of this work was to assess the test-retest reproducibility of QSM in the Italian AD-NET project, a multi-site study on AD. We evaluated how QSM reproducibility is affected by acquisition (different clinical 3T MRI sites using vendor provided sequences) and analyses factors (choice of the reference region of interest used to compute within-subject relative QSM). The goal is to minimize reproducibility errors and thus maximize the sensitivity to detect longitudinal QSM changes related to the progression of AD.

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