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Abstract #1995

Quantitative T1 and T2 mapping with standard and MR fingerprinting techniques to assess frontotemporal dementia: A pilot study

Stilyana Peteva Bakoeva1, Vera Catharina Keil1, Alina Jurcoane1, Mariya Doneva2, Thomas Amthor2, Peter Koken2, Burkhard Mädler3, Wolfgang Block1, Klaus Fließbach4, and Elke Hattingen1

1Department of Radiology, University Hospital Bonn, Bonn, Germany, 2Philips Research, Hamburg, Germany, 3Philips Healthcare, Bonn, Germany, 4Department of Psychiatry, University Hospital Bonn, Bonn, Germany

This pilot study explored the utility of MR fingerprinting (MRF) and standard T1 and T2 relaxometry to discover focal anomalies in patients with the primary progressive aphasic form of frontotemporal dementia (FTD). MRF and standard techniques revealed longer T1 and T2 relaxation times of cortex and deep white matter as well as the hippocampus (left>right) in FTD compared to healthy controls. Relaxation times between MRF and standard differed and not all techniques revealed all structures as altered in relaxation time. In conclusion, MRF and standard relaxometry have the potential to quantify brain anomalies in FTD, which may be used for diagnosis and monitoring, but are not interchangeable.

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