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Abstract #1998

Riluzole improved Energy Metabolism in AβPP-PS1 Mouse Model of Alzheimer’s Disease

Anant Bahadur Patel1 and Kamal Saba1

1NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, India

Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by degeneration of neurons leading to memory loss, deterioration in cognitive function and behavior. Despite intensive research of several decades treatment of AD is still a major challenge. Riluzole is known to be neuro-protector and regulates the function of glutamatergic neurons by reducing glutamate release and helping astroglial uptake. In this study, we have evaluated the impacts of Riluzole on the neuronal activity in the AβPP-PS1 mouse model of the AD by 1H-[13C]-NMR spectroscopy together with infusion of [1,6-13C2]glucose. The finding of improved neurometabolism in AD mice suggests riluzole improved cognitive function in Alzheimer's disease.

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