Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by degeneration of neurons leading to memory loss, deterioration in cognitive function and behavior. Despite intensive research of several decades treatment of AD is still a major challenge. Riluzole is known to be neuro-protector and regulates the function of glutamatergic neurons by reducing glutamate release and helping astroglial uptake. In this study, we have evaluated the impacts of Riluzole on the neuronal activity in the AβPP-PS1 mouse model of the AD by 1H-[13C]-NMR spectroscopy together with infusion of [1,6-13C2]glucose. The finding of improved neurometabolism in AD mice suggests riluzole improved cognitive function in Alzheimer's disease.