Meeting Banner
Abstract #2002

A combined dual-tracer PET/diffusion tractometry analysis of the posterior cingulum in a mild cognitive impairment ketogenic intervention

Maggie Roy1, Stephen Cunnane1, Étienne Croteau1, Alexandre Castellano1, Mélanie Fortier1, Félix C Morency2, Jean-Christophe Houde1, and Maxime Descoteaux1

1Université de Sherbrooke, Sherbrooke, QC, Canada, 2Imeka Solutions Inc., Sherbrooke, QC, Canada

In mild cognitive impairment (MCI), posterior cingulate cortex glucose hypometabolism may results from posterior cingulum (PCg) alterations. We suggest that raising ketone availability to the brain may overcome the brain energy deficit. We developed a dual-tracer PET/dMRI tractometry method to assess whether a ketogenic supplement has impact on fuel uptake in the PCg of MCI participants. Mean fuel uptake in the PCg was unchanged post-supplementation, but tract-profiling enabled the identification of sections with lower glucose uptake. Energy supply in white matter fascicles is crucial to sustain adequate axonal function and may be linked to the pathogenesis of MCI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here