Abstract #2001

Changes in hippocampal and whole brain stiffness in 14-month old female mice with Alzheimer’s disease

Miklos Palotai¹, Katharina Schregel^1,2, Navid Nazari^1,3, Julie P. Merchant⁴, Walter M. Taylor⁴, Charles R.G. Guttmann¹, Ralph Sinkus⁵, Tracy L. Young-Pearse⁴, and Samuel Patz¹

¹Department of Radiology, Brigham and Women`s Hospital, Harvard Medical School, Boston, MA, United States, ²Institute of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany, ³Department of Biomedical Engineering, Boston University, Boston, MA, United States, ⁴Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ⁵Department of Radiological Imaging, Imaging Sciences & Biomedical Engineering Division, King's College London, London, United Kingdom

Alzheimer’s disease (AD) has been associated with human brain softening, but the underlying biomechanical mechanism is not fully elucidated. We used magnetic resonance elastography to investigate the effect of amyloid-beta accumulation on hippocampal and whole brain (WB) stiffness in transgenic AD and wild-type (WT) mice at 11 and 14 months of age. The only differences observed between AD and WT mice were that the longitudinal change in the loss modulus between 11 and 14 months for female AD mice was significantly different than that of either the WT or male AD mice.

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