In this study, we recruited seven subjects with MCI and ten subjects as cognitive normal groups. All subjects underwent PASL and T1-weighted MR imaging. Multimodal images were upload to MRICloud for segmentation and quantification of regional CBF. T-test was used to detect significant changes in brain region volumes and perfusion asymmetries in contralateral regions. We observed tendencies of atrophy in right posterior cingulate cortex and dilation in bilateral fornix, significant perfusion asymmetries were found in regions of temporal lobe, basal ganglia and posterior cingulate cortex among MCI subjects.