Recent research has been focused on developing diagnostics based on amyloid-β and tau. However, metabolic and vascular changes pre-date both by several decades. The aim of this study was to exploit the coupling between glucose uptake in aerobic glycolysis and cerebral blood flow to produce a biomarker for metabolic dysfunction and amyloid-β deposition. Here we found that a decrease in glucose uptake in the presence of stable blood flow is spatially correlated with an increase in amyloid-β deposition and that uncoupling between metabolic and vascular function could drive amyloid-β deposition.
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