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Abstract #2004

Prediction of Cognitive Impairment and Amyloid Deposition through Metabolic and Vascular Deficits in ADNI Cohorts

David Ma1,2 and Ai-Ling Lin1

1Sanders Brown Center on Aging, Lexington, KY, United States, 2Paul Laurence Dunbar High School, Lexington, KY, United States

Recent research has been focused on developing diagnostics based on amyloid-β and tau. However, metabolic and vascular changes pre-date both by several decades. The aim of this study was to exploit the coupling between glucose uptake in aerobic glycolysis and cerebral blood flow to produce a biomarker for metabolic dysfunction and amyloid-β deposition. Here we found that a decrease in glucose uptake in the presence of stable blood flow is spatially correlated with an increase in amyloid-β deposition and that uncoupling between metabolic and vascular function could drive amyloid-β deposition.

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