Anatomical MRI and PET data from the genetic cohort of the ADNI database was analyzed for MRI volumetric, FDG-PET, and AV-45 differences between HFEH63D polymorphism and HFEWT carriers. A decrease in the amount of AV-45 amyloid binding was observed in the AD HFEH63D carriers as well as an increase in FDG metabolism and a decrease in regional brain volume. HFEH63D appears to be preservative in AD with respect to PET imaging biomarkers, but there was a negative interaction in the VBM analysis. This reinforces the hypothesis that HFEH63D has a preservative effect in AD.
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