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Abstract #2005

MRI and PET alterations in Alzheimer’s disease and cognitive normal HFEH63D polymorphism carriers

Carson J Purnell1, Qing X Yang2, James R Connor1, and Mark D Meadowcroft1,2

1Neurosurgery, The Pennsylvania State University - College of Medicine, Hershey, PA, United States, 2Radiology, The Pennsylvania State University - College of Medicine, Hershey, PA, United States

Anatomical MRI and PET data from the genetic cohort of the ADNI database was analyzed for MRI volumetric, FDG-PET, and AV-45 differences between HFEH63D polymorphism and HFEWT carriers. A decrease in the amount of AV-45 amyloid binding was observed in the AD HFEH63D carriers as well as an increase in FDG metabolism and a decrease in regional brain volume. HFEH63D appears to be preservative in AD with respect to PET imaging biomarkers, but there was a negative interaction in the VBM analysis. This reinforces the hypothesis that HFEH63D has a preservative effect in AD.

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