Abstract #2008

Investigation of cerebral perfusion differences between the 2xTg Alzheimer’s disease mouse model and age-matched controls using FAIR ASL MRI

Diana Y. Lee¹, Abinand C. Rejimon¹, Rebecca L. McPherson², Kenneth W. Fishbein¹, Mustapha Bouhrara¹, Simonetta Camandola³, Mark P. Mattson³, Edward G. Lakatta², Olga V. Fedorova², and Richard G. Spencer¹

¹Laboratory of Clinical Investigation, Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, The National Institutes of Health, Baltimore, MD, United States, ²Laboratory of Cardiovascular Science, National Institute on Aging, The National Institutes of Health, Baltimore, MD, United States, ³Laboratory of Neuroscience, National Institute on Aging, The National Institutes of Health, Baltimore, MD, United States

Cerebral blood flow (CBF) is an emerging biomarker of Alzheimer’s disease (AD). To correlate CBF to other known measures of AD, such as cortical thinning and volume loss, we assessed perfusion differences between a 2xTg-AD mouse model and age-matched wild-type mice using a FAIR RARE MRI sequence. Our results demonstrate greater systolic blood pressure (SBP) in AD mice as they age as well as hypoperfusion within the cerebral cortex at 12 months of age.

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