Abstract #2009

Quantitative Susceptibility Mapping to evaluate the Iron deposition and Venous Blood Oxygenation in the brain for the differentiation of Mild Cognitive Impairment and Alzheimer’s disease: A pilot study

Sheelakumari R¹, Bejoy Thomas¹, Ramshekhar Menon², Ramesh Venkatesan³, and Chandrasekharan Kesavadas¹

¹Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India, ²Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India, ³GE Healthcare, Banglore, India

Oxygen extraction fraction (OEF) in the brain can be obtained by Quantitative Susceptibility Mapping (QSM). QSM can also estimate iron which is implicated in the pathogenesis of Alzheimer’s disease and its pre-symptomatic antecedents. The differences of OEF and iron values among the controls, Mild Cognitive Impairment and AD were investigated by ROI based comparisons using a one-way analysis of variance. These values in the posterior brain regions were found to have a trend towards increment in patient groups compared with controls, in this pilot study. Future studies are required to validate the usefulness of this technique as potential biomarker.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.