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Abstract #2010

APOE ε4 Allele Effect on White Matter Perfusion and Diffusion in Cognitively Normal and MCI Groups

Youngkyoo Jung1, Jeongchul Kim1, Megan E Johnston1, Christopher T Whitlow1, Laura D Baker2, and Suzanne Craft2

1Radiology, Wake Forest School of Medicine, Winston-Salem, NC, United States, 2Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States

Hypo-perfusion was observed among APOE ε4 carriers in both white and gray matter from the previous study in cognitively normal and mild cognitive impairment groups. Diffusion tensor imaging metrics in the white matter was further examined in the hypo-perfusion region and compared with perfusion metrics. Multiple statistical trends match with the observations from the perfusion metrics, which may suggest evidence of that a perfusion abnormality among APOE ε4 carriers may precedes the disruption of white matter integrity in the group.

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