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Abstract #2016

Higher temporal lobe curvature in early Alzheimer's indicative of subsequent cognitive decline

Christopher Bird1, Sarah J Banks1, Dietmar Cordes1,2, Karthik Sreenivasan1, Xiaowei Zhang1, Zhengshi Yang1, and Virendra Mishra1

1Cleveland Clinic, Las Vegas, NV, United States, 2University of Colorado Boulder, Boulder, CO, United States

We selected ADNI patients with an initial diagnosis of mild cognitive impairment (MCI) due to early Alzheimer’s disease, a positive amyloid PET scan within 4 years, and comparable cognitive test scores during their initial visit. Patients were grouped according to their diagnosed outcome within 4 years of the initial visit, specifically, MCI subsequently diagnosed with dementia and stable MCI. We found that curvature within the temporal lobe was greater among patients subsequently diagnosed with dementia. Established measurements of atrophy, including hippocampal volume and temporal lobe thickness, did not differ between these groups.

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