Abstract #2017

Functional and structural deficits in a novel transgenic rat model of Alzheimer’s Disease.

Cynthia Anckaerts¹, Ines Blockx^1,2, Christina Kreutzer³, Hervé Boutin⁴, Sébastien Couillard-Despres³, Marleen Verhoye¹, and Annemie Van der Linden¹

¹Bio-Imaging Lab, University of Antwerp, Wilrijk, Antwerp, Belgium, ²Department of Radiology, NYU Langone Medical Center, Center for Biomedical Imaging, New York, NY, United States, ³Spinal Cord Injury and Tissue Regeneration Center Salzburg; Institute of Experimental Neuroregeneration; Paracelsus Medical University, Salzburg, Austria, ⁴Wolfson Molecular Imaging Centre, University of Manchester, Manchester, United Kingdom

As improving our understanding of the underlying mechanisms of Alzheimer’s Disease (AD) pathology is of utmost importance, the development and characterization of innovative animal models is essential in AD-related research. Here, we further characterized a novel transgenic rat model of AD, the TgF344-AD rat, which manifests progressive AD pathology, much akin to human AD. Functional and structural deficits along the disease progression were assessed using resting state functional MRI (rsfMRI) and diffusion tensor imaging, respectively.

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