The aim of this study is to evaluate the atrophy pattern of hippocampal subfield and follow up the changes of hippocampal subfield by using automatic segmentation tool in patients with mild AD. The results indicate that volumes of hippocampal subfield decrease in patients with mild AD, and the declination are positive correlated with clinical scores. We conclude that substructures of hippocampal might serve as a good index to characterize subtle changes in AD patients.
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