We investigated structural and functional brain network architecture in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI); and assessed the relationship between healthy brain network functional connectivity and the topography of brain atrophy in patients along the AD continuum. Structural connectivity alterations distinguished MCI who converted to AD from those who did not. Brain regions most strongly connected with the disease-epicenter (left hippocampus) in the healthy functional connectome were also the most atrophic in both AD and converters MCI. Graph theoretical analysis provides insight on how neurodegeneration propagates across the human brain in the early phase of AD.
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