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Abstract #2032

Effects of perivascular progenitor cells in combination with Abeta clearance on neurovascular function following transient hypertension in a transgenic rat model of Alzheimer’s Disease

Tina L Beckett1, Paolo Bazzigaluppi1, Margaret Koletar1, Conner Robert Adams2, Lynsie Thomason1, Adrienne Dorr1, Denis Gallagher3, Clifford Librach1,3, JoAnne McLaurin1,4, and Bojana Stefanovic1,2

1Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3CReATe Research Program, Toronto, ON, Canada, 4Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

Examining the interplay between cerebrovascular compromise and AD in the development of therapies is complicated by long prodromal phases of both conditions, necessitating preclinical studies. Four-month-old TgAD-F344 rats, which by six months of age present amyloid deposits and hyperphosphorylated tau, were treated with a nitric oxide synthase inhibitor L-NAME for one month to induce transient hypertension. Human umbilical cord perivascular cells were then given in combination with scyllo-inositol, an inhibitor of Abeta peptide oligomerization and fibrillization to elicit cerebrovascular repair and clear amyloid. Following L-NAME, non-transgenic rats showed transient cerebrovascular changes, whereas TgAD-F344 animals exhibited sustained increase in cerebrovascular reactivity. The latter effect was ameliorated by the treatment.

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