Abstract #2033

Diffusion MRI Changes in the Brain of the 3xTg Mouse Model of Alzheimer’s Disease

Xingju Nie^1,2, Maria Fatima Falangola^1,2, Emilie T. McKinnon^1,2,3, Joseph A. Helpern^1,2,3, and Jens H. Jensen^1,2

¹Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States, ²Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States, ³Department of Neurology, Medical University of South Carolina, Charleston, SC, United States

The triple transgenic mouse model (3xTg) of Alzheimer’s disease (AD) exhibits both Aβ and tau pathology. Although diffusion MRI (dMRI) is an established tool for tracking changes in brain microstructure for aging and AD in humans, prior research using diffusion tensor imaging has called into question the sensitivity of dMRI for 3xTg mice. Here we investigated the sensitivity of an alternative dMRI method, diffusional kurtosis imaging, to detect brain changes associated with aging and disease progression in 3xTg mice. Our results indicate that dMRI is able to capture age and/or pathology related alterations in brain tissue for this mouse model.

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