Abstract #2038

Combined MRI and Ultrasound Measurements to Assess the Impact of Systemic Chemotherapy on the Developing Brain and Heart

Leigh Spencer Noakes¹, Thomas Przybycien², Amanda Forwell³, Yu-Qing Zhou¹, Ellen van der Plas², and Brian J. Nieman^1,4

¹The Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada, ³University of Waterloo, Waterloo, ON, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada

Combined multiple-mouse ex vivo MRI and high-frequency cardiac ultrasound were used to assess the impact of common chemotherapy agents on the developing brain and heart. Of the eight agents considered, vincristine had the most widespread impact on the brain. Doxorubicin, methotrexate, and L-asparaginase were also found to impact brain and/or heart development.

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