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Abstract #2038

Combined MRI and Ultrasound Measurements to Assess the Impact of Systemic Chemotherapy on the Developing Brain and Heart

Leigh Spencer Noakes1, Thomas Przybycien2, Amanda Forwell3, Yu-Qing Zhou1, Ellen van der Plas2, and Brian J. Nieman1,4

1The Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3University of Waterloo, Waterloo, ON, Canada, 4Medical Biophysics, University of Toronto, Toronto, ON, Canada

Combined multiple-mouse ex vivo MRI and high-frequency cardiac ultrasound were used to assess the impact of common chemotherapy agents on the developing brain and heart. Of the eight agents considered, vincristine had the most widespread impact on the brain. Doxorubicin, methotrexate, and L-asparaginase were also found to impact brain and/or heart development.

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