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Abstract #2056

Regional Brain Iron Mapping in Patients with Heart Failure

Bhaswati Roy1, Sadhana Singh2, Xiaopeng Song2, Ashish Sahib2, Cristina Cabrera-Mino1, Gregg C. Fonarow3, Mary Woo1, and Rajesh Kumar2,4,5,6

1UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States, 2Department of Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, 3Division of Cardiology, University of California at Los Angeles, Los Angeles, CA, United States, 4Department of Radiological Sciences, University of California at Los Angeles, Los Angeles, CA, United States, 5Department of Bioengineering, University of California at Los Angeles, Los Angeles, CA, United States, 6Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States

HF subjects show brain injury in multiple areas, which may contribute to altered iron concentration in those sites. However, regional brain iron load in HF subjects is unclear. We examined regional iron deposition using R2*-relaxometry procedures and found altered R2*-values in the amygdala, brainstem, thalamus, globus pallidus, hippocampus, cerebellum, insula, and frontal and temporal white matter regions. The altered iron concentration in HF subjects may result from neural and white matter injury, including myelin and glial dysfunction, with iron potentially accelerating tissue degeneration. These data suggest that interfering with the iron action may reduce the exacerbation of injury in HF.

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