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Abstract #2059

Impact of coregistration approaches on the reliability of R2* and Quantitative Susceptibility Maps (QSM) at 7 T

Seongjin Choi1, Xu Li2,3, and Daniel M Harrison1

1Department of Neurology, University of Maryland Baltimore, Baltimore, MD, United States, 2Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We assessed the unexplored reliabilities of QSM and R2* map acquired at 7 T by two different approaches that are 1) a direct coregistration of the quantitative maps from their native to a reference space and 2) processing the quantitative maps in a transformed space. R2* was reliable in both methods in the pixel value and the group-mean analyses. However, QSM was less reliable when it was processed in a transformed space in both analyses. Therefore, QSM is recommended to be calculated in its native space prior to any coregistration in a multi-modal study.

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