Abstract #2059

Impact of coregistration approaches on the reliability of R2* and Quantitative Susceptibility Maps (QSM) at 7 T

Seongjin Choi¹, Xu Li^2,3, and Daniel M Harrison¹

¹Department of Neurology, University of Maryland Baltimore, Baltimore, MD, United States, ²Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We assessed the unexplored reliabilities of QSM and R2* map acquired at 7 T by two different approaches that are 1) a direct coregistration of the quantitative maps from their native to a reference space and 2) processing the quantitative maps in a transformed space. R2* was reliable in both methods in the pixel value and the group-mean analyses. However, QSM was less reliable when it was processed in a transformed space in both analyses. Therefore, QSM is recommended to be calculated in its native space prior to any coregistration in a multi-modal study.

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