Abstract #2068

Nonlinear pattern of the emergence of white matter hyperintensity in healthy Han Chinese: an adult lifespan study

Chu-Chung Huang¹, Albert C. Yang², Kun-Hsien Chou³, Mu-En Liu⁴, Shih-Jen Tsai⁴, and Ching-Po Lin⁵

¹Aging and Health Research Center, National Yang-Ming University, Taipei, Taiwan, ²Division of Interdiscplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, ³Brain Research Center, National Yang-Ming University, Taipei, Taiwan, ⁴Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ⁵Insitute of Neuroscience, National Yang-Ming University, Taipei, Taiwan

WMH is one of the most obvious imaging traits in the aged brain. There is evidence that the WMH volume may have the potential to track with age and age-related cognitive decline. However, no study has investigated the trajectory of WMH progression and their impact on cognition during normal aging process. We show that increased age is nonlinearly correlated with increased PVWMH. In two-mediators mediation model, PVWMH is found to mediate the age-related decline of MMSE, but not DWMH. This study suggested that PVWMH could be a potential, and feasible biomarker in predicting age-related cognitive decline across the adult lifespan.

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