Coma after cardiac arrest is a common and debilitating incidence. This study aims to determine the neurochemical changes that occur in comatose cardiac arrest patients who underwent targeted temperature management. Single Voxel MRS was acquired in the posterior cingulate gyrus (PCG) and parietal white matter (PWM) of patients and age-matched controls with no history of neurological disease. Patients showed decreases in NAA, as well as increases in total Choline and Lactate in both PCG and PWM. Patients also showed decreases in glutamate in the PCG. These neurometabolic changes reflect neuronal, axonal and glial loss that would result in reduced neurotransmission.