Meeting Banner
Abstract #2070

Cerebral Vascular Reactivity and Cognitive Decline in Healthy and in Early Stages of Pathological Aging.

Naila Boudiaf1, Jan Warnking2, Olivier Moreaud3, Johan Pietras4, Eric Condamine2, Nathalie Fournet5, Amandine Bossant6, Monica Baciu7, and Alexandre Krainik1

1Neuroradiology, CHU Grenoble, Grenoble, France, 2Grenoble Institute of Neuroscience, Grenoble, France, 3Neurology, CMRR Grenoble, CHU Grenoble, Grenoble, France, 4IRMAGE, Grenoble, France, 5CNRS, LPNC, Chambéry, France, 6CHU Grenoble, Grenoble, France, 7CNRS, LPNC, Grenoble, France

Cerebral blood flow (CBF) and cerebral vascular reactivity (CVR) decrease with age and might affect cognitive functions. In this study, we investigated their correlation with cognitive abilities during normal and pathological aging.

We performed neuropsychological assessments on thirty-four participants: 13 healthy-young, 10 healthy-old and 11 impaired-old. We measured CBF and CVR using hypercapnia and Arterial Spin Labeling imaging.

Regarding the impaired-old, we found specific decrease in executive functions, short-term and working memory. Significant correlations were found between CVR and cognitive scores. Global CBF correlated only with age.

Unlike CBF, CVR reduction was specifically associated with cognitive decline during aging.

This abstract and the presentation materials are available to members only; a login is required.

Join Here