Lactoferrin (Lf) is an iron-binding glycoprotein secreted in milk known as antioxidant, antimicrobial and anti-inflammatory. Infants exposed to adverse prenatal conditions of intrauterine growth restriction (IUGR), are at high risk for neurological morbidities. The aim of this work was to assess neuroprotective effect of Lf on brain microstructure by using diffusion imaging and NODDI model at 9.4T in a model of 50% gestational caloric restriction. Diffusion MRI derived parameters changes following IUGR were partially restored in the Lf supplemented group, providing evidence of a neuroprotective effect.
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