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Abstract #2075

Differentiation of white matter hyperintensity severity using T2- and T1-weighted brain MRI.

Nina Linde Højland Reislev1,2, Henrik Lundell1, Hartwig Roman Siebner1,3, Christian Eriksen2,4, Michael Kjær2,4, and Ellen Garde2,5

1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 2Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 3Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, 4Institute for Sports Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, 5Department of Public Health, University of Copenhagen, Copenhagen, Denmark

This study presents a new method to differentiate brain white matter hyperintensity (WMH) severity using conventional T1-weighted and T2-weighted MRI. By combining normalized image intensity, heterogeneous tissue properties within lesions are revealed. Lesion severity is quantified through two distance measures of parallel and perpendicular deviation from normal appearing white matter. Correlations with diffusion imaging based measures suggest that multi-modal voxel-based lesion analysis provide comparable but high-resolution tissue information. Based on conventional MRI scans this method adds valuable insight into the differentiated impact of WMH lesions on brain structure and function.

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