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Abstract #2076

The Aging Brain: Cerebrovascular responses to CO2.

Larissa McKetton1, Olivia Sobczyk2, Julien Poublanc1, Kevin Sam2,3, Adrian P. Crawley1, Lakshmikumar Venkat Raghavan4, James Duffin4,5, Joseph A. Fisher2,4,5, and David J. Mikulis4,5

1Division of Neuroradiology, Joint Department of Medical Imaging, University Health Network, Toronto, ON, Canada, 2Institute of Medical Science, University of Toronto, Toronto, ON, Canada, 3The Russell H. Morgan Department of Radiology & Radiological Science, The John Hopkins University School of Medicine, Baltimore, MD, United States, 4Department of Anaesthesia and Pain Management, University Health Network, Toronto, ON, Canada, 5Department of Physiology, University of Toronto, Toronto, ON, Canada

Measures of cerebrovascular reactivity (CVR) are used to judge the health of the brain vasculature. We report the use of several different analyses of BOLD responses to CO2 to provide a number of metrics for various aspects of CVR. To assess possible differences in these metrics with age, we compiled atlases reflecting voxel-wise means and standard deviations for different age ranges and compared them.

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