Abstract #2084

Increased Glutamate in Anterior Cingulate Cortex in Crohn’s Disease Patients with Abdominal Pain Revealed by Proton MR Spectroscopy

Kun Lv¹, Wenwen Song², Yihong Fan³, Yong Zhang⁴, Bin Lv³, and Maosheng Xu²

¹Zhejiang Chinese Medical University, Hangzhou, China, ²Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China, ³Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China, ⁴MR research, GE Healthcare, Shanghai, China

Based on Brain-gut axis, the study used proton magnetic resonance (MR) spectroscopy, a noninvasive detection to reveal the alteration of metabolites in bilateral perigenual anterior cingulate cortex (pgACC) in patients with Crohn’s disease (CD) with abdominal pain. Twenty nine CD patients (cases with/without abdominal pain, 16/13) and 20 healthy controls were recruited for comparison. The pain CD group showed increased Glutamate (Glu) levels in bilateral pgACC, which might provide new insight into the neural mechanism of the disease in abdominal pain processing.

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