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Abstract #2085

Changes in Quantitative Free Water Content with Increasing BMI in Elderly Subjects

Melissa Schall1, Elene Iordanishvili1, Svenja Caspers2, N. Jon Shah1,3, and Ana-Maria Oros-Peusquens1

1Institute of Medical Imaging Physics INM-4, Research Centre Jülich, Jülich, Germany, 2Institute of Neuroscience and Medicine (INM-4), Research Centre Jülich, Jülich, Germany, 3Jülich Aachen Research Alliance (JARA), Jülich, Germany

A high body mass index is known to play a role in a variety of chronic diseases, which makes it an important biomarker. Using a 3D two-point quantitative mapping method, changes in several parameters including relaxation times, H2O and magnetisation transfer measures were investigated in lean and obese subjects. Preliminary results show a significant increase of H2O in corpus callosum (p<0.05), thalamus (p<0.005) and white matter of temporal lobe (p<0.05) with increasing BMI. Changes in the other parameters did not reach significance. These findings suggest the existence of regional low-grade brain inflammation in obesity.

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