Abstract #2092

Concept of Gadolinium-Ferritin Interactions as Explanation of Signal Intensity Changes in Deep Brain Nuclei after Application of Gadolinium-Based Contrast Agents

Josef Vymazal¹, Jitka Neburkova², Martin Dracinsky², Mohan Pingle³, Petr Cigler⁴, and Aaron Michael Rulseh¹

¹Dept. of Radiology, Na Homolce Hospital, Prague, Czech Republic, ²Insittute of Organic Chemistry and Biochemistry, Prague, Czech Republic, ³Dept. of Radiology, Na Homolce Hospital, Praha, Czech Republic, ⁴Petr Cigler, Insittute of Organic Chemistry and Biochemistry, Prague, Czech Republic

Interaction between gadolinium-based contrast agents and metalloprotein ferritin may explain observed signal intensity changes in vivo due to T1 (and T2) shortening in the globus pallidus and dentate nucleus.

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