Applying the quantitative blood-oxygenation-level-dependent (qBOLD) method for measuring the oxygen extraction fraction (OEF) often suffers from bad contrast due to the low SNR typical at clinical scan times. In order to improve the evaluation, the choice of the weighting factors in a proposed regularization approach was analyzed. Using the regularization approach, simulations showed increasing precision but decreasing accuracy for increasing weighting factors. For a range of weighting factors a good trade-off between noise suppression and data-fidelity was achieved, which resulted in optimal contrast.
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