Relaxometry aims at an absolute quantification of T1 and T2 times explained by physicochemical properties in the brain. MR Fingerprinting can be used for quantitative relaxometry, e.g. to explore the effect of age on brain structure. This study examined young and old age (n=26 each) volunteers with standard and MRF mapping techniques. We found that MRF and standard technique multiecho-derived T1 and T2 maps do not identify the same brain structures as affected by age-related relaxometric changes and show in part contradictory relationships between age and especially T1 relaxation. This limited comparability has strong clinical implications for the interpretation of relaxometric studies beyond the topic "aging".
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