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Abstract #2094

Visualizing healthy aging: A comparative study of quantitative T1 and T2 relaxometry with standard and MR fingerprinting techniques

Vera Catharina Keil1, Stilyana Peteva Bakoeva1, Alina Jurcoane1, Thomas Amthor2, Mariya Doneva2, Peter Koken2, Burkhard M├Ądler3, Wolfgang Block1, and Elke Hattingen1

1Department of Radiology, University Hospital Bonn, Bonn, Germany, 2Philips Research, Hamburg, Germany, 3Philips Healthcare, Bonn, Germany

Relaxometry aims at an absolute quantification of T1 and T2 times explained by physicochemical properties in the brain. MR Fingerprinting can be used for quantitative relaxometry, e.g. to explore the effect of age on brain structure. This study examined young and old age (n=26 each) volunteers with standard and MRF mapping techniques. We found that MRF and standard technique multiecho-derived T1 and T2 maps do not identify the same brain structures as affected by age-related relaxometric changes and show in part contradictory relationships between age and especially T1 relaxation. This limited comparability has strong clinical implications for the interpretation of relaxometric studies beyond the topic "aging".

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