Abstract #2098

Simultaneous assessment of tDCS-induced neuronal responses with oxygen metabolic MRI

Yulin Ge¹, Abhishek Datta², Bryan Dobbs³, Michael Shaw³, Ashley Clayton³, Oded Gonen³, and Leigh Charvet³

¹Radiology, New York University School of Medicine, New York City, NY, United States, ²Soterix Medical, New York City, NY, United States, ³New York University School of Medicine, New York City, NY, United States

Although transcranial direct current stimulation (tDCS) offers a therapeutic solution in many neurological diseases, it is still poorly understood how tDCS works underlying neuronal activity in real time. This work was to investigate the real-time tDCS (during stimulation) neuronal response measured with oxygen metabolic MRI. We found cerebral metabolic rate of oxygen (CMRO₂) increased during tDCS as compared to sham and immediately reduced when tDCS was turned off but remained at slightly higher level than pre-tDCS. The results strongly support our hypothesis that electric current stimulation can induce neuronal activity and CMRO₂ increase.

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