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Abstract #2099

Visualizing the effects of ultrasound-based peripheral neuromodulation in the brain

Ileana Hancu1, Vickie Cotero1, Suresh Joel2, Chitresh Bhushan1, Jeanette Roberts1, Ying Fan1, Sireesha Kaanumalle1, Jeffrey Ashe1, and Chris Puleo1

1GE Global Research Center, Niskayuna, NY, United States, 2GE Global Research Center, Bangalore, India

We have demonstrated visualization of functional brain changes caused by non-invasive, ultrasound-based stimulation of specific axonal projections within the liver. Following lipopolysaccharide (LPS) injections in a rat animal model, the site-specific liver ultrasound (US) stimulation affected blood glucose levels. The glucose concentration changes were accompanied by increases in the apparent diffusion coefficients (ADC’s) in the paraventricular nucleus (PVN), a known center of afferent nerve pathway termination for integration of outgoing systemic signaling. The local sites of neuronal de-activation (as highlighted by diffusion fMRI) were confirmed by reduced hypothalamic cFOS staining (a marker of neuronal activation).

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