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Abstract #2104

Comparison of intravenous and intraperitoneal routes of Omniscan administration with respect to its retention in the rat brain

Serguei Liachenko1, Natalya Sadovova1, Sherry Ferguson1, Joseph Hanig2, Merle G Paule1, Olayinka Dina3, Anthony Fotenos3, Adebayo Laniyonu3, and Ira Krefting3

1Neurotoxicology, NCTR / FDA, Jefferson, AR, United States, 2OTR, CDER / FDA, White Oak, MD, United States, 3DMIP, CDER / FDA, White Oak, MD, United States

Preclinical investigation into the brain retention of gadolinium contrast agents after repeated dosing requires extensive animal handling, particularly for intravenous injections. To decrease the potential stress caused by surgical implantation of intravenous catheters and constant maintenance of those catheters for repeated dosing, we proposed to administer Omniscan for such studies via the intraperitoneal route to laboratory rodents. After 20 dosed over 5 weeks, Omniscan retention was similar in both routes of administration.

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