Abstract #2105

Quantitative T2 mapping can reliably detect the retention of Omniscan in the rat brain

Serguei Liachenko¹, Natalya Sadovova¹, Sherry Ferguson¹, Joseph Hanig², Zhen He¹, Merle G Paule¹, Olayinka Dina³, Anthony Fotenos³, Adebayo Laniyonu³, and Ira Krefting³

¹Neurotoxicology, NCTR / FDA, Jefferson, AR, United States, ²OTR, CDER / FDA, White Oak, MD, United States, ³DMIP, CDER /FDA, White Oak, MD, United States

Current methods of investigating brain retention of gadolinium-based contrast agents use T₁-weighted MRI, and rarely T₁ quantitative mapping. The former does not provide easily quantifiable data and the latter require prolonged scanning time. We proposed the use of a simple ‘off-the-shelf’ T₂ mapping technique to reliably quantify relaxation changes in the rat brain due to gadolinium accumulation. The sensitivity of this method is much better compared to the commonly used T₁-weighted MRI.

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