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Abstract #2105

Quantitative T2 mapping can reliably detect the retention of Omniscan in the rat brain

Serguei Liachenko1, Natalya Sadovova1, Sherry Ferguson1, Joseph Hanig2, Zhen He1, Merle G Paule1, Olayinka Dina3, Anthony Fotenos3, Adebayo Laniyonu3, and Ira Krefting3

1Neurotoxicology, NCTR / FDA, Jefferson, AR, United States, 2OTR, CDER / FDA, White Oak, MD, United States, 3DMIP, CDER /FDA, White Oak, MD, United States

Current methods of investigating brain retention of gadolinium-based contrast agents use T1-weighted MRI, and rarely T1 quantitative mapping. The former does not provide easily quantifiable data and the latter require prolonged scanning time. We proposed the use of a simple ‘off-the-shelf’ T2 mapping technique to reliably quantify relaxation changes in the rat brain due to gadolinium accumulation. The sensitivity of this method is much better compared to the commonly used T1-weighted MRI.

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