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Abstract #2106

Pharmacological MRI response of raclopride in rat: relationship with D2 receptor occupancy or cataleptic behavior

Yukiko Masaki1, Yuto Kashiwagi1, Takemi Rokugawa1, and Kohji Abe1

1SHIONOGI & CO., LTD., Osaka, Japan

Pharmacological MRI allows the visualization of brain pharmacological effects of drugs using fMRI. In order to clarify the relationship between fMRI signal and receptor occupancy or behavioral response, we performed [11C]-raclopride PET, fMRI and the behavioral assessment with raclopride, dopamine D2 receptor antagonist. The positive fMRI response and cataleptic behavior were observed at the dose of raclopride showing 83% of D2 receptor occupancy, but not at the dose of raclopride showing 42% of D2 receptor occupancy. These results suggest that fMRI and behavioral response induced by raclopride will be needed the high D2 receptor occupancy.

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