Pharmacological MRI allows the visualization of brain pharmacological effects of drugs using fMRI. In order to clarify the relationship between fMRI signal and receptor occupancy or behavioral response, we performed [11C]-raclopride PET, fMRI and the behavioral assessment with raclopride, dopamine D2 receptor antagonist. The positive fMRI response and cataleptic behavior were observed at the dose of raclopride showing 83% of D2 receptor occupancy, but not at the dose of raclopride showing 42% of D2 receptor occupancy. These results suggest that fMRI and behavioral response induced by raclopride will be needed the high D2 receptor occupancy.
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