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Abstract #2107

Simian immunodeficiency virus infection transiently increases brain temperature in rhesus macaques as detected with magnetic resonance spectroscopy thermometry

Dionyssios Mintzopoulos1,2, Gilberto Gonzalez2,3, Eva-Maria Ratai2,3, and Marc J Kaufman1,2

1McLean Imaging Center, McLean Hospital, Belmont, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

Our prior proton Magnetic Resonance Spectroscopy (MRS) studies in Simian Immunodeficiency Virus (SIV)-infected macaques reported higher brain choline and myo-inositol levels at 2 weeks post-infection, suggestive of ongoing inflammation. As brain inflammation has been associated with brain hyperthermia, we used Magnetic Resonance Spectroscopy Thermometry retrospectively to determine whether SIV infection increases brain temperature. At 2 weeks post-infection, we detected increased brain temperature in the frontal and parietal cortex, basal ganglia, and in white matter, relative to pre-infection temperatures. Brain temperatures were strongly correlated with choline levels, suggesting that SIV transiently increases brain temperature by increasing brain inflammation.

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