Abstract #2114

Monitoring LPS-induced gray matter inflammation through endogenous contrasts: MT, CEST and NOE

Chenwang Jin^1,2, Yanrong Chen^1,3, Chenyan Chu¹, Piotr walzcak¹, and Xiaolei Song¹

¹Morgan Department of Radiology and Radiological Science, Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering,The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Medical Imaging, The First Affiliated Hospital of Xian Jiaotong University, Xian, China, ³School of information and technology,The Northwest University, Xian, China

Gray matter (GM) damage is a common phenomenon and clinically relevant in the onset and progression of many neuroinflammation diseases, including Multiple Sclerosis, Alzheimer’s Disease and Depression. However, conventional MRI techniques are insensitive to the detection of GM damage. Chemical exchange saturation transfer (CEST) is an innovative molecular MRI technique that bridges the tissue microstructure and cellular metabolic function, possibly allowing sensing metabolic changes. Our preliminary results suggest that NOE-MRI (Nuclear Overhauser Effect, NOE) may provide a novel biomarker in detection of slight inflammatory changes in cortex and deep GM and also potentially enable quantifing the diffusive GM damages.

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