Abstract #2115

Differential Effects of (+)MK801 and (-)MK801 on Brain Structure and Metabolism in Adolescence Rats As Revealed by VBM Analysis and In Vivo 1H-MRS

Yijuan Zou^1,2 and Hao Lei^1,2

¹Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China, ²State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China

N-methyl-Daspartate receptor (NMDAR) antagonists, such as phencyclidine (PCP), ketamine and dizocilpine (MK801), have been widely used for inducing schizophrenia animal models. As a noncompetitive selective NMDAR antagonist, MK801 has two stereoisomers, (+)MK801 and (-)MK801, which have been found to induce different behavioral phenotypes and histological changes in animals. In this study, we compared differential effects of (+)MK801 and (-)MK801 on brain structure and metabolism in adolescence rats with MRI/in vivo ¹H-MRS. The results showed that (+)MK801 induced more severe gray matter (GM) atrophy and more evident metabolic changes than (-)MK801, and the different effects were related to their potency at NMDA receptors.

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