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Abstract #2115

Differential Effects of (+)MK801 and (-)MK801 on Brain Structure and Metabolism in Adolescence Rats As Revealed by VBM Analysis and In Vivo 1H-MRS

Yijuan Zou1,2 and Hao Lei1,2

1Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China, 2State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China

N-methyl-Daspartate receptor (NMDAR) antagonists, such as phencyclidine (PCP), ketamine and dizocilpine (MK801), have been widely used for inducing schizophrenia animal models. As a noncompetitive selective NMDAR antagonist, MK801 has two stereoisomers, (+)MK801 and (-)MK801, which have been found to induce different behavioral phenotypes and histological changes in animals. In this study, we compared differential effects of (+)MK801 and (-)MK801 on brain structure and metabolism in adolescence rats with MRI/in vivo 1H-MRS. The results showed that (+)MK801 induced more severe gray matter (GM) atrophy and more evident metabolic changes than (-)MK801, and the different effects were related to their potency at NMDA receptors.

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