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Abstract #2116

Apparent Diffusion Coefficient Correlates with Histological Tumor Burden at the Infiltrating Margins of a Preclinical Glioblastoma Model

Gerard Thompson1, Antoine Vallatos1, Haitham Al-Mubarak2, Lesley Gilmour3, Joanna Birch3, Lindsay Gallagher2, James Mullin2, Adam Waldman1, William M Holmes2, and Anthony J Chalmers3

1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2Glasgow Experimental MRI Centre, University of Glasgow, Glasgow, United Kingdom, 3Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom

Assessing the imaging boundary of glioblastoma multiforme (GBM) has potential to characterize phenotypic invasiveness relevant to outcomes. Preoperative apparent diffusion coefficient (ADC) changes across this boundary predicts outcome in humans. The tissue specificity of this finding is unknown, hindering the interpretation, further development, and application of the technique. We selected and assessed a relevant preclinical murine infiltrating GBM orthotopic human xenograft model with a novel histological tissue tumor load assessment to investigate relationships between ADC on imaging and cellular infiltration. A robust and strong inverse correlation between the histological tumor infiltration measure and ADC transition is demonstrated, supporting the hypothesis that ADC changes across GBM boundaries represent tumor infiltration and therefore relate to the previously-proposed invasive phenotype imaging biomarker.

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