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Abstract #2121

Diffusion tensor imaging reveals altered brain development of MECP2 overexpressing rat in cerebellar and limbic structures

Jian-kun Dai1, Yu-yan Chen1, and Zhifeng Liang1

1Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, China

In this study, we used diffusion tensor imaging to investigate the effect of MECP2 overexpressing (MECP2-OE) on the rat brain development. Our results showed the MECP2-OE mainly affected the cerebellar fiber tracts and limbic structures. Behavior tests showed the MECP2-OE rats presented significant defects of social interaction than the wild type (WT) rats.

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