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Abstract #2122

A novel transgenic rat model of evolving cerebral amyloid angiopathy (CAA)

Hedok Lee1, Xiaodan Liu1, Simon Sanggaard1, Sunil Koundal1, Feng Xu2, William Van Nostrand2, and Helene Benveniste1

1Yale University, New Haven, CT, United States, 2University of Rhode Island, Kingston, RI, United States

Understanding the pathophysiology of cerebral amyloid angiopathy (CAA) has become increasingly important because there is evidence to suggest that vascular dysfunction plays an important role in early component in the development of Alzheimer’s disease (AD). To study CAA, Tg-SwDI transgenic mouse model was recently extended to rat (Tg-DI) and here we report the first MRI studies to characterize CAA in Tg-DI in both in vivo as well as in vitro using 3D-GRE sequence. Conspicuous lesions were detected in thalamus in Tg-DI at very early stage, consisting of multiple pathological changes including micro-bleeds, extravasation of blood products and/or occluded vessels.

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