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Abstract #2128

Abnormal growth trajectories of white matter in spontaneously hypertensive rats when compared to non-hypertensive controls: Implications for small vessel disease progression

Sunil Koundal1, Simon Sanggaard1,2, Kristian Mortensen2, Helene Benveniste1, Maiken Nedergaard2,3, and Hedok Lee1

1Yale University, New Haven, CT, United States, 2University of Copenhagen, Copenhagen, Denmark, 3University of Rochester, Rochester, NY, United States

The spontaneously hypertensive rat (SHR) is a clinically relevant animal model in studying small vessel disease. Whole brain morphological differences between SHR compare to normotensive Wistar-Kyoto (WKY) rats were evaluated in parallel with development of chronic hypertension. Voxel-wise deformation based morphometry indicated progressive enlargement of the cerebral ventricles in SHR compare to WKY, and a fraction of the body and splenium of corpus callosum in SHRs were significantly smaller in the middle-aged rats but not in young-aged rats.

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