The spontaneously hypertensive rat (SHR) is a clinically relevant animal model in studying small vessel disease. Whole brain morphological differences between SHR compare to normotensive Wistar-Kyoto (WKY) rats were evaluated in parallel with development of chronic hypertension. Voxel-wise deformation based morphometry indicated progressive enlargement of the cerebral ventricles in SHR compare to WKY, and a fraction of the body and splenium of corpus callosum in SHRs were significantly smaller in the middle-aged rats but not in young-aged rats.
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